4-Chloro-2-nitroanisole → 5-Chloro-2-methoxyaniline

HRID 2057571

반응식

HRID 2057571 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-])=O)[CH:3]=1>[Ni]>[NH2:10][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

참가 물질

3

반응물 1

HCID 666314-Chloro-2-nitroanisole

생성물 1

HCID 667635-Chloro-2-methoxyaniline

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

0.037 mol (7 g) of 4-chloro-2-nitroanisole is dissolved in 100 ml of absolute alcohol and 3 g of nickel prepared by the RANEY process are added. The solution is hydrogenated at atmospheric pressure and at room temperature while stirring. The catalyst is separated and then washed with two portions of 20 ml of boiling ethanol. The alcoholic solution is concentrated under reduced pressure; the 2-amino-4-chloroanisole crystallizes.

후처리

  1. additionare added
  2. customis hydrogenated at atmospheric pressure and at room temperature
  3. customThe catalyst is separated
  4. washwashed with two portions of 20 ml of boiling ethanol
  5. concentrationThe alcoholic solution is concentrated under reduced pressure
  6. customthe 2-amino-4-chloroanisole crystallizes

출처 및 근거

ORD 기록
ord-8d2027cedc054e0d925f8ce20ae21344
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04211776

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