Hydrazine hydrate (1:1) → 4-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 2058608

반응식

HRID 2058608 반응식
O.NN.[CH3:4][N:5]1[C:9]([C:10]([NH2:12])=[O:11])=[C:8]([N+:13]([O-])=O)[C:7]([CH3:16])=[N:6]1>[Ni].C(O)C>[NH2:13][C:8]1[C:7]([CH3:16])=[N:6][N:5]([CH3:4])[C:9]=1[C:10]([NH2:12])=[O:11]

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 12297641,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

생성물 1

HCID 138229254-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

1.1 ml of hydrazine hydrate are added dropwise at 60° to 75° C. to a suspension of 2.0 g of 1,3-dimethyl-4-nitropyrazole-5-carboxamide and approximately 0.2 g of moist Raney nickel in 15 ml of ethanol; the solution is kept at the boil for 1.5 hours and is filtered. The filtrate is concentrated to dryness in vacuo, and 1.3 g of the hydrochloride, mp 232° to 234° C. (dec.), are precipitated by means of an ethereal solution of hydrogen chloride.

후처리

  1. filtrationis filtered
  2. concentrationThe filtrate is concentrated to dryness in vacuo, and 1.3 g of the hydrochloride, mp 232° to 234° C. (dec.)
  3. customare precipitated by means of an ethereal solution of hydrogen chloride

출처 및 근거

ORD 기록
ord-bfaac7d74ddd4b6e9b2de57841993ab2
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04317823

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