Iodoethane → N-alpha-methoxyethyl-N-etyl-acetamide

HRID 2059120노트

반응식

HRID 2059120 반응식
[CH3:1][O:2][CH:3]([NH:5][C:6](=[O:8])[CH3:7])[CH3:4].[CH2:9](I)[CH3:10].[OH-].[Na+]>>[CH3:1][O:2][CH:3]([N:5]([CH2:9][CH3:10])[C:6](=[O:8])[CH3:7])[CH3:4]

참가 물질

4

반응물 3

HCID 6340IodoethaneHCID 14798Sodium HydroxideHCID 10986197N-(1-methoxyethyl)acetamide

생성물 1

HCID 20545711N-alpha-methoxyethyl-N-etyl-acetamide수율 51%

실험 절차

58.5 g (0.5 mole) of N-α-methoxyethyl-acetamide and 84.2 g (0.55 mole) of ethyl iodide are simultaneously added dropwise to 300 ml of 50% strength sodium hydroxide solution at 10° C. Two hours after the addition has ended, the phases are separated in a separating funnel, the aqueous portion is extracted with hexane and, after stripping off the solvent, the residue is distilled in vacuo. 37 g (51% of theory) of N-α-methoxyethyl-N-etyl-acetamide of boiling point16 83°-85° C. are obtained.

후처리

  1. additionTwo hours after the addition
  2. customthe phases are separated in a separating funnel
  3. extractionthe aqueous portion is extracted with hexane
  4. distillationthe residue is distilled in vacuo

출처 및 근거

ORD 기록
ord-f06fcf4e2e72499496476b956ef3c985
출처 데이터셋
uspto-grants-1982_03
특허 번호
US04322271

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