4-(Trifluoromethyl)benzaldehyde → 201164-14-9

HRID 2059451노트

반응식

HRID 2059451 반응식
O=Cc1ccc(C(F)(F)F)cc1.CON(C)C(=O)CC(=O)O>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>CON(C)C(=O)/C=C/c1ccc(C(F)(F)F)cc1

참가 물질

6

반응물 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 11263568HCID 11263568, 화합물

생성물 1

HCID 9449823201164-14-9수율 84%

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine시약HCID 31268Pyrrolidine촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
25 °C

후처리

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 상 유지
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

출처 및 근거

ORD 기록
ord-9d20ca01e16f441283e2119c56489b27
출처 데이터셋
Transfer learning optimization of 26 decarboxylative olefination reactions

반응 노트

불러오는 중…