Hydrochloric Acid → 1-(4-methanesulfonyl-phenyl)-1H-pyrazole
반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].CO[CH:15](OC)[CH2:16][CH:17](OC)OC.Cl>C(O)C>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH:17]=[CH:16][CH:15]=[N:12]2)=[CH:9][CH:10]=1)(=[O:4])=[O:3]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 4-(methylsulfonyl)phenylhydrazine (5.0 g, 26.8 mmol, 1.00 equiv) and 1,1,3,3-tetramethoxypropane (4.4 mL, 26.8, 1.0 equiv) in ethanol (37 mL) at rt was added concentrated HCl (2.8 mL). The resulting solution was heated at reflux for 1 hr, cooled to 0° C. and filtered to give 1-(4-methanesulfonyl-phenyl)-1H-pyrazole as a yellow solid (4.73 g, 79%). LCMS: (MH)+=223.1 (1.19 min).
후처리
- temperatureThe resulting solution was heated
- temperatureat reflux for 1 hr
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-cf5f16db644e423890a415b90ce6cc83
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08278337B2
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