Hydrochloric Acid → HCID 178516753, 화합물

HRID 2060250

반응식

HRID 2060250 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=O)=[CH:4][CH:3]=1.[NH2:12][CH2:13][C:14]([NH2:16])=[O:15].[OH-].[Na+].Cl.C(=O)(O)[O-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[CH:13][C:14]([OH:15])=[N:16][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69020GlycinamideHCID 269588(4-Chlorophenyl)(oxo)acetaldehydeHCID 516892Sodium Bicarbonate

생성물 1

HCID 178516753HCID 178516753, 화합물수율 37.2%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
-30 °C

실험 절차

To a stirred solution of (4-chloro-phenyl)-oxo-acetaldehyde (300 mg, 1.69 mmol) in methanol (15 mL) was added 2-amino-acetamide (187 mg, 1.69 mmol). The resulting mixture was cooled to −30° C. and 12.5M aqueous sodium hydroxide solution (0.3 mL) added. The resulting mixture was allowed to warm to −5° C. and was stirred at this temperature for 2 hours, followed by stirring at room temperature for 2 hours. Concentrated aqueous hydrogen chloride (0.3 mL) was added, followed by saturated sodium bicarbonate solution (1.0 mL). The reaction mixture was filtered and the resulting solid was washed with water (10 mL) and dried in a vacuum oven to afford the title compound as a brown solid (130 mg, 37%)

후처리

  1. temperatureto warm to −5° C.
  2. stirringby stirring at room temperature for 2 hours
  3. filtrationThe reaction mixture was filtered
  4. washthe resulting solid was washed with water (10 mL)
  5. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-bacc7dfb8db14fada60bd2545ce4e55c
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278343B2

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