Methyl iodide → HCID 178503939, 화합물

HRID 2061161노트

반응식

HRID 2061161 반응식
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[CH:5]=[C:4]([C:13]2[CH:14]=[C:15]([NH:20][C:21]([NH:23][C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[S:22])[CH:16]=[CH:17][C:18]=2[CH3:19])[C:3]1=[O:32].[OH-].[Na+].[CH3:35]I>C(Cl)Cl>[C:24](/[N:23]=[C:21](\[S:22][CH3:35])/[NH:20][C:15]1[CH:16]=[CH:17][C:18]([CH3:19])=[C:13]([C:4]2[C:3](=[O:32])[N:2]([CH3:1])[C:11]3[C:6]([CH:5]=2)=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=3)[CH:14]=1)(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 59212331HCID 59212331, 화합물

생성물 1

HCID 178503939HCID 178503939, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)benzamide 20 (22 mg, 0.05 mmol) in DCM (0.5 mL) was added solid powder of NaOH (20 mg, 0.5 mmol) and MeI (7 mg, 0.05 mmol). The mixture was stirred at rt for 1 h to yield (Z)-methyl N′-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamimidothioate 21 after removal of DCM. The crude 21 was used without further purification. MS m/z 457.2 (M+1).

출처 및 근거

ORD 기록
ord-db42613024ce49dea5a0727bc206f829
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278452B2

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