Hydrazine hydrate (1:1) → 2371-31-5

HRID 2061406

반응식

HRID 2061406 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12]CC)=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([NH:16][NH2:17])=[O:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester

생성물 1

HCID 3026472371-31-5수율 59%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-(4-chlorophenylamino)acetate (A) (25.6 g, 120 mmol) and hydrazine monohydrate (7.0 mL, 144 mmol) were heated to reflux in ethanol (120 mL) for 22 hours. After concentration in vacuo, the solid obtained was recrystallised from ethanol to yield the title compound (14.0 g, 59%) as a pale brown powder. 1H NMR (400 MHz, CDCl3) δ 3.85 (2H, d), 4.18 (2H, br), 6.53 (2H, d), 7.16 (2H, d), 7.60 (1H, br).

후처리

  1. concentrationAfter concentration in vacuo
  2. customthe solid obtained
  3. customwas recrystallised from ethanol

출처 및 근거

ORD 기록
ord-4de39e719876495c897ec661c521281c
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283351B2

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