Sodium Hydroxide → Ertapenem disodium

HRID 2068128노트

반응식

HRID 2068128 반응식
[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([NH:18][C:19]3[CH:20]=[CH:21][CH:22]=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=3)=[O:17])[CH2:12]2)=[C:8]([C:28]([OH:30])=[O:29])[N:7]2[C@H:3]1[C@@H:4]([C@H:31]([OH:33])[CH3:32])[C:5]2=[O:6].[Na].[OH-].[Na+:36]>C(=O)(O)[O-].[Na+]>[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25]([O-:27])=[O:26])[CH:22]=[CH:21][CH:20]=3)=[O:17])[CH2:12]2)=[C:8]([C:28]([O-:30])=[O:29])[N:7]2[C@H:3]1[C@@H:4]([C@H:31]([OH:33])[CH3:32])[C:5]2=[O:6].[Na+:36].[Na+:36]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 665981361-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)-

생성물 1

HCID 150611Ertapenem disodium

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

실험 절차

To the solution of sodium bicarbonate (2.5 g in 70 mL water) Ertapenem monosodium (15 g) was slowly added at 0-5° C., by maintaining pH around 7.5 using sodium hydroxide solution. The solution obtained was subjected to carbon treatment, followed by stirred with alumina and filtered. To filtrate, containing Ertapenem disodium was filtered through 0.2 micron filter paper and added into 2500 mL of cold IPA solution at 0-5° C. The solid obtained was filtered washed with IPA followed by acetone and IPE, dried under dry and wet nitrogen to yield Ertapenem disodium (Yield—8-12 g; sodium content: 9.2-10.5%; moisture content: 5-7%; pH: 7.5-8.0). The color of the reconstituted product was pale yellow.

후처리

  1. temperatureby maintaining pH around 7.5
  2. customThe solution obtained
  3. filtrationfiltered
  4. additionTo filtrate, containing Ertapenem disodium
  5. filtrationwas filtered through 0.2 micron
  6. filtrationfilter paper
  7. additionadded into 2500 mL of cold IPA solution at 0-5° C
  8. customThe solid obtained
  9. filtrationwas filtered
  10. washwashed with IPA
  11. customdried
  12. customunder dry

출처 및 근거

ORD 기록
ord-25eb0003c4a14a91b78c164bc984c6a8
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293924B2

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