Butyl bromide → 4-Bromo-1-butoxy-2-fluorobenzene

HRID 2068451

반응식

HRID 2068451 반응식
[OH-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([F:11])[CH:5]=1.Br[CH2:13][CH2:14][CH2:15][CH3:16]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:13][CH2:14][CH2:15][CH3:16])=[C:6]([F:11])[CH:5]=1

참가 물질

6

반응물 3

HCID 8002Butyl bromideHCID 14798Sodium HydroxideHCID 27249814-Bromo-2-fluorophenol

생성물 1

HCID 120674454-Bromo-1-butoxy-2-fluorobenzene수율 98.6%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

Sodium hydroxide (20.2 g) was added to a water (400 ml) solution of 4-bromo-2-fluorophenol (T-7) (76.4 g), bromobutane (65.8 g) and tetrabutylammonium bromide (TBAB) (6.44 g), and the mixture was heated with stirring at 80° C. for 6 hours under an atmosphere of nitrogen. After the completion of the reaction, the reaction mixture was extracted with heptane, and the organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to leave a black oil. The oil was purified by distillation to give 4-bromo-1-butoxy-2-fluorobenzene (T-8) as a colorless oil (97.5 g) in 98% yield.

후처리

  1. temperaturethe mixture was heated
  2. customAfter the completion of the reaction
  3. extractionthe reaction mixture was extracted with heptane
  4. washthe organic layer was washed with water and brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationThe solution was concentrated under reduced pressure
  7. customto leave a black oil
  8. distillationThe oil was purified by distillation

출처 및 근거

ORD 기록
ord-c6198ca4fe1649789b46752ecb41c113
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08298632B2

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