Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid

HRID 2068635

반응식

HRID 2068635 반응식
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>>[O:13]1[CH:14]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[N:11]=[CH:12]1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 581102445-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester

생성물 1

HCID 581102215-Oxazol-4-yl-thiophene-3-carboxylic acid수율 100.2%

실험 절차

5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).

후처리

  1. customThe mixture was quenched with HCl (1 N, 0.35 mL)
  2. concentrationconcentrated
  3. customazeotroping twice with methanol

출처 및 근거

ORD 기록
ord-a9e15b923af248999376c9b186edc511
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299063B2

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