Hydrochloric Acid → 2-(3-Bromo-5-methoxyphenyl)ethan-1-amine

HRID 2069079노트

반응식

HRID 2069079 반응식
C1COCC1.[Br:6][C:7]1[CH:8]=[C:9]([CH2:15][C:16]#[N:17])[CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1.Cl.[OH-].[Na+]>C(OCC)(=O)C.CO>[Br:6][C:7]1[CH:8]=[C:9]([CH2:15][CH2:16][NH2:17])[CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 212429652-(3-Bromo-5-methoxyphenyl)acetonitrile

생성물 1

HCID 106094762-(3-Bromo-5-methoxyphenyl)ethan-1-amine

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

A borane-tetrahydrofuran complex (1 M, 73.6 mL) was added to a THF (36.8 mL) solution of Intermediate 3 at room temperature and the resulting mixture was stirred to reflux at 80° C. for 2 hours. Methanol (26 mL) and 1 N hydrochloric acid (26 mL) were added to the reaction mixture solution and the resulting mixture was stirred at room temperature for 1 hour. The resulting mixture was neutralized with 1 N aqueous sodium hydroxide solution followed by the addition of ethyl acetate (100 mL) to extract the reaction mixture, the organic layer was dried, and then the solvent was evaporated under reduced pressure to give the title compound (8.76 g).

후처리

  1. stirringthe resulting mixture was stirred at room temperature for 1 hour
  2. extractionto extract the reaction mixture
  3. customthe organic layer was dried
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-311631ca28cd4032830eee9f6352f8bd
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299055B2

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