4-Butoxybenzoic acid → N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide

HRID 2069324

반응식

HRID 2069324 반응식
[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[B-](F)(F)(F)F.CCOC(C(C#N)=NOC(N(C)C)=[N+](C)C)=O.C(N(CC)C(C)C)(C)C.[CH3:46][N:47]([CH3:63])[CH:48]1[CH2:52][CH2:51][N:50]([C:53]2[CH:62]=[CH:61][C:56]([C:57]([NH:59][NH2:60])=[O:58])=[CH:55][CH:54]=2)[CH2:49]1>O.CN(C=O)C>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([C:10]([NH:60][NH:59][C:57](=[O:58])[C:56]2[CH:55]=[CH:54][C:53]([N:50]3[CH2:51][CH2:52][CH:48]([N:47]([CH3:46])[CH3:63])[CH2:49]3)=[CH:62][CH:61]=2)=[O:12])=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

7

반응물 4

HCID 729714-Butoxybenzoic acidHCID 81531DiisopropylethylamineHCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 692131084-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

생성물 1

HCID 69208757N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-butoxybenzoic acid (156 mg) and DMF (10 ml) was mixed with TOTU (264 mg) and N,N-diisopropylethylamine (104 mg). After 10 minutes, 4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide (200 mg) was added. After one hour, the mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate, filtered and concentrated. The product with the molecular weight of 424.55 (C24H32N4O3) was obtained in this way; MS (ESI): 425 (M+H+).

후처리

  1. waitAfter one hour
  2. extractionextracted with ethyl acetate
  3. washThe organic phase was washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe product with the molecular weight of 424.55 (C24H32N4O3) was obtained in this way

출처 및 근거

ORD 기록
ord-a46ea26eb7344cf78e64e0e56da54b45
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299104B2

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