Hydroxyamine hydrochloride → 1-(5-(Prop-1-en-2-yl)pyridin-3-yl)ethanone oxime
반응식
[CH2:1]=[C:2]([C:4]1[CH:5]=[C:6]([C:10](=O)[CH3:11])[CH:7]=[N:8][CH:9]=1)[CH3:3].[NH2:13][OH:14].Cl>CCO.O.[OH-].[Na+]>[CH2:1]=[C:2]([C:4]1[CH:5]=[C:6]([C:10](=[N:13][OH:14])[CH3:11])[CH:7]=[N:8][CH:9]=1)[CH3:3]참가 물질
6
실험 절차
To a stirred solution of 1-(5-(prop-1-en-2-yl)pyridin-3-yl)ethanone (460 mg, 2.86 mmol) in 95% EtOH was added a solution of NH2OH.HCl (1.19 g, 17.14 mmol) in a mixture of water (5.8 mL) and 10% NaOH (5.8 mL) and refluxed for 2.5 h. All solvent was removed. The residue was dissolved in CHCl3, washed with water, dried with Na2SO4 and concentrated under reduced pressure to yield 400 mg of crude 1-(5-(prop-1-en-2-yl)pyridin-3-yl)ethanone oxime.
후처리
- temperaturerefluxed for 2.5 h
- customAll solvent was removed
- dissolutionThe residue was dissolved in CHCl3
- washwashed with water
- dry with materialdried with Na2SO4
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-e147ab0d50b442a9884cffd846ce1bdc
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08299267B2
반응 노트
불러오는 중…