Ammonia → 3-Methoxyestra-2,5(10)-dien-17beta-ol

HRID 2072266

반응식

HRID 2072266 반응식
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:18]2[C:17]3[CH2:16][CH2:15][C@@:13]4([CH3:14])[C@@H:9]([CH2:10][CH2:11][C@@H:12]4[OH:21])[C:8]=3[CH2:7][CH2:6][C:5]=2[CH:4]=1.N.[Li+].CC[O-].[Al]>[Pt].C(O)C>[CH3:1][O:2][C:3]1[CH2:4][C:5]2[CH2:6][CH2:7][C@@H:8]3[C@@H:17]([C:18]=2[CH2:19][CH:20]=1)[CH2:16][CH2:15][C@@:13]1([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]1[OH:21]

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 5359268AluminumHCID 110552063-Methoxyestra-1,3,5(10),8-tetraen-17beta-olHCID 23661847Lithium ethoxide

생성물 1

HCID 1019633-Methoxyestra-2,5(10)-dien-17beta-ol

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

2.0 g. of 3-methoxy-1,3,5(10),8-estratetraen-17β-ol is electrolyzed in 200 ml. of liquid ammonia and 20 ml. of ethanol in the presence of 2 g. of lithium ethylate and 0.5 g. of lithium anilide for 3 hours in an undivided cell between an aluminum cathode and a platinum anode, with a current density of 2.5 A/cm2. After the reaction mixture has been worked up, 1.8 g. of 3-methoxy-2,5(10)-estradien-17β-ol is isolated, m.p. 110° C.

출처 및 근거

ORD 기록
ord-c8055da511c743a99c5b97a5b7660e3c
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04050998

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