Hydrochloric Acid → HCID 131710913, 화합물

HRID 2072488노트

반응식

HRID 2072488 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH2:8][CH2:7][CH2:6]2.[ClH:16].[CH3:17][NH:18][CH3:19].[CH2:20]=O.Cl>CC(C)=O.C(O)C>[ClH:16].[CH3:17][N:18]([CH2:20][CH:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:4]=2)[C:9]1=[O:13])[CH3:19]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 712Formaldehyde2회HCID 10473Dimethylamine, hydrochlorideHCID 149151176-(Trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

생성물 1

HCID 131710913HCID 131710913, 화합물수율 77.3%

시약·촉매·용매 2

HCID 180Acetone용매HCID 702Ethanol용매

실험 절차

A mixture of 6-(trifluoromethyl)-1-tetralone (0.90 g), dimethylamine hydrochloride (0.42 g), paraformaldehyde (0.16 g), and 95% ethanol (2 ml) containing concentrated hydrogen chloride (0.02 ml) is heated on a steam bath for 1 1/2 hours. The reaction mixture soon becomes homogeneous and the paraformaldehyde dissolves. The warm solution is diluted with acetone (15 ml) and cooled to yield the title compound as white needles (1.0 g) melting point 137°-138° C.

후처리

  1. temperatureis heated on a steam bath for 1 1/2 hours
  2. temperaturecooled

출처 및 근거

ORD 기록
ord-d1e58b26508347cbbd8b91c582559e2c
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051248

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