Ethyl Thioglycolate → 2-(4,5-Diphenyl-1,3-oxazol-2-ylthio)acetic acid

HRID 2072543

반응식

HRID 2072543 반응식
C([O:3][C:4](=[O:7])[CH2:5][SH:6])C.[H-].[Na+].[H][H].Cl[C:13]1[O:14][C:15]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1.BrC1OC(C2C=CC=CC=2)=C(C2C=CC=CC=2)N=1>CN(C=O)C>[C:18]1([C:16]2[N:17]=[C:13]([S:6][CH2:5][C:4]([OH:3])=[O:7])[O:14][C:15]=2[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

7

반응물 5

HCID 12185Ethyl ThioglycolateHCID 24758Sodium hydrideHCID 131311622-Chloro-4,5-diphenyloxazoleHCID 214087062-Bromo-4,5-diphenyl-oxazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 7224662-(4,5-Diphenyl-1,3-oxazol-2-ylthio)acetic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

12 g. of thioglycolic acid ethyl ester is added to a suspension of 2.4 g. of NaH in 200 ml. of freshly distilled DMF, and the mixture is agitated until the evolution of hydrogen has ceased. Thereafter, 25.5 g. of 2-chloro-4,5-diphenyl-oxazole or 30 g. of 2-bromo-4,5-diphenyl-oxazole is added to the mixture. The latter is agitated for 5 hours at 80° and worked up as usual, thus obtaining the ethyl ester of 4,5-diphenyl-2-oxazolylmercaptoacetic acid, b.p. 207°-210°/0.1 mm.; m.p. 54°-56° (hexane).

출처 및 근거

ORD 기록
ord-e09b04154b454e03ae2e01d90bd3bfe6
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051250

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