Hydrochloric Acid → 2-(2-(3-((Quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionic acid

반응식

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:32]=[CH:33][CH:34]=1)[O:16][CH2:17][C:18]1[CH:31]=[CH:30][CH:29]=[CH:28][C:19]=1[O:20][CH:21]([CH3:27])[C:22]([O:24]CC)=[O:23].[OH-].[Na+].Cl>CCO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:32]=[CH:33][CH:34]=1)[O:16][CH2:17][C:18]1[CH:31]=[CH:30][CH:29]=[CH:28][C:19]=1[O:20][CH:21]([CH3:27])[C:22]([OH:24])=[O:23]

참가 물질

실험 절차

To a solution of (2.65 mmol) of the ester from step C in 25 ml of EtOH is added 10 ml (10.0 mmol, 3.75 equiv) of 1N NaOH. The mixture is stirred for 1 hour at room temperature which time the mixture is acidified to pH~4 using 1N HCl. A precipitate forms which is filtered off and recrystallized from hot MeOH-Et2O to afford 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionic acid.