Hydroxyamine hydrochloride → 4-{3-[2-Amino-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

HRID 2075676노트

반응식

HRID 2075676 반응식
C(=[N:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:32][C:33]3[CH:34]=[C:35]([C:39]4([C:45]#[N:46])[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)[CH:36]=[CH:37][CH:38]=3)=[CH:20][CH:21]=2)[N:16]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.NO.C([O-])(=O)C.[K+]>CO>[NH2:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:32][C:33]3[CH:34]=[C:35]([C:39]4([C:45]#[N:46])[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[CH:36]=[CH:37][CH:38]=3)=[CH:20][CH:21]=2)[N:16]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 866138284-{3-[2-(Benzhydrylidene-amino)-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

생성물 1

HCID 670907114-{3-[2-Amino-4-(4-fluoro-phenyl)-quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3d (300 mg, 0.48 mmol), hydroxylamine hydrochloride (67 mg, 0.97 mmol), and potassium acetate (92 mg, 0.97 mmol) was dissolved in MeOH (10 mL) and stirred overnight at room temperature. The reaction was concentrated and purified by silica gel chromatography (30% EtOAc in hexanes) to obtain the desired product, 3e.

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified by silica gel chromatography (30% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-4854c5b9dc39445192c0f643efdcd576
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919621B2

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