홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-Isoxazolamine, 5-(1,1-dimethylethyl)- → HCID 24953743, 화합물

HRID 2076802
노트
인쇄 미리보기

반응식

HRID 2076802 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][C@@H:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10]2)=[CH:4][CH:3]=1.[C:21]([C:25]1[O:29][N:28]=[C:27]([NH2:30])[CH:26]=1)([CH3:24])([CH3:23])[CH3:22].C[Si]([N-][Si](C)(C)C)(C)C.[Na+]>CS(C)=O>[C:21]([C:25]1[O:29][N:28]=[C:27]([NH:30][C:2]2[CH:3]=[CH:4][C:5]([CH2:8][N:9]3[CH2:14][CH2:13][O:12][C@@H:11]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH2:10]3)=[CH:6][N:7]=2)[CH:26]=1)([CH3:24])([CH3:23])[CH3:22]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-HCID 2724254Sodium bis(trimethylsilyl)amideHCID 59177295HCID 59177295, 화합물

생성물 1

HCID 24953743HCID 24953743, 화합물수율 24%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
60 °C

실험 절차

2.73 mL of (S)-4-(6-Chloro-pyridin-3-ylmethyl)-2-phenyl-morpholine in DMSO(0.1M solution) was added to 63 mg of 5-tert-Butyl-isoxazol-3-ylamine. 900 L of sodium bis(trimethylsilyl)amide (1M solution in tetrahydrofuran) was added and the reaction heated overnight at 60° C. on an orbital shaker. The reaction was filtered through a fritted cartridge. Purification was accomplished by preparatory liquid chromatography to give the title compound in 24% yield. EI m/z 393=MH+

후처리

  1. filtrationThe reaction was filtered through a fritted cartridge
  2. customPurification

출처 및 근거

ORD 기록
ord-a8b8860f62c44208a1608f90c159c538
출처 데이터셋
uspto-grants-2011_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07928103B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트