Hydrogen Bromide → 2-Amino-5-bromo-3-fluorobenzoic acid

HRID 2079623

반응식

HRID 2079623 반응식
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 5864082-Amino-3-fluorobenzoic acid

생성물 1

HCID 404245972-Amino-5-bromo-3-fluorobenzoic acid수율 95%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a suspension of 2-amino-3-fluorobenzoic acid (5 g, 32.2 mmol) in chloroform (200 mL) was added dropwise bromine (1.1 equiv.) in chloroform (125 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 9.6 g of white powder as HBr salt of 2-amino-5-bromo-3-fluorobenzoic acid (95% yield). ES/MS m/z 234/236 (MH+).

후처리

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed thoroughly with methylene chloride until the filtrate
  3. customThe solid was air-dried

출처 및 근거

ORD 기록
ord-465e8168695f4c588921e7bc7792097b
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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