Hydrogen Bromide → 2-Amino-5-bromo-3-chlorobenzoic acid
반응식
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
5
실험 절차
To a suspension of 2-amino-3-chlorobenzoic acid (2 g, 11.6 mmol) in chloroform (120 mL) was added dropwise bromine (1.1 equiv.) in chloroform (12 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 3.35 g of white powder as HBr salt of 2-amino-5-bromo-3-chlorobenzoic acid (87% yield). ES/MS m/z 250/252 (MH+).
후처리
- filtrationThe resulting white solid was collected by filtration
- washwashed thoroughly with methylene chloride until the filtrate
- customThe solid was air-dried
출처 및 근거
- ORD 기록
- ord-3f417d96222c474b91be7cd3eaffa9f3
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07932262B2
반응 노트
불러오는 중…