Hydrogen Bromide → 2-Amino-5-bromo-3-chlorobenzoic acid

HRID 2079625

반응식

HRID 2079625 반응식
[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([Cl:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 808072-Amino-3-chlorobenzoic acid

생성물 1

HCID 8279792-Amino-5-bromo-3-chlorobenzoic acid수율 87%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a suspension of 2-amino-3-chlorobenzoic acid (2 g, 11.6 mmol) in chloroform (120 mL) was added dropwise bromine (1.1 equiv.) in chloroform (12 mL) solution. The mixture was stirred at room temperature for 16 hrs. The resulting white solid was collected by filtration and washed thoroughly with methylene chloride until the filtrate was colorless. The solid was air-dried to give 3.35 g of white powder as HBr salt of 2-amino-5-bromo-3-chlorobenzoic acid (87% yield). ES/MS m/z 250/252 (MH+).

후처리

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed thoroughly with methylene chloride until the filtrate
  3. customThe solid was air-dried

출처 및 근거

ORD 기록
ord-3f417d96222c474b91be7cd3eaffa9f3
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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