Hydrochloric Acid → 2-Amino-6-(2-cyanoethyl)-nicotinic Acid

HRID 2079951노트

반응식

HRID 2079951 반응식
[OH-].[Na+].C[O:4][C:5](=[O:17])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]#[N:15])=[N:8][C:7]=1[NH2:16].Cl>CO>[NH2:16][C:7]1[N:8]=[C:9]([CH2:12][CH2:13][C:14]#[N:15])[CH:10]=[CH:11][C:6]=1[C:5]([OH:17])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 583879902-Amino-6-(2-cyanoethyl)-nicotinic acid methyl ester

생성물 1

HCID 231303622-Amino-6-(2-cyanoethyl)-nicotinic Acid수율 81%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solvent mixture of 2N-sodium hydroxide aqueous solution (5 mL) and methanol (5 mL) was added 2-amino-6-(2-cyanoethyl)-nicotinic acid methyl ester (90 mg, 0.439 mmol), and the solution was stirred for 18 hours at room temperature. This mixed solution was neutralized with 5N-hydrochloric acid, then, extracted with ethyl acetate. This organic layer was dried over anhydrous magnesium sulfate, then, the solvent was evaporated in vacuo, and the title compound (68 mg, 0.355 mmol, 81%) was obtained as a yellowish brown solid.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThis organic layer was dried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-f7c01d8bc5624e4db515dffa190e9139
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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