5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine
반응식
[CH2:1]([C:8]1[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15].CO>[Ni]>[CH2:1]([C:8]1[O:12][C:11]([CH2:13][NH2:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.
후처리
- customAfter removing the catalyst
- filtrationby filtering through Celite pad
- customthe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-fa9049e0f9524da9bf4ee48ab4ee6885
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07932272B2
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