5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine

HRID 2080254

반응식

HRID 2080254 반응식
[CH2:1]([C:8]1[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15].CO>[Ni]>[CH2:1]([C:8]1[O:12][C:11]([CH2:13][NH2:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 124185375-Benzylfuran-2-carbaldehydeHCID 21705897Ammonia methanol

생성물 1

HCID 231306205-(Phenylmethyl)-2-furanmethanamine수율 65.8%

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.

후처리

  1. customAfter removing the catalyst
  2. filtrationby filtering through Celite pad
  3. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-fa9049e0f9524da9bf4ee48ab4ee6885
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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