Stannous Chloride → HCID 57770617, 화합물

HRID 2092622노트

반응식

HRID 2092622 반응식
[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:7]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH:12]=[C:13]([NH2:15])[CH:14]=1)=[O:8])[CH3:5].[N:23]([O-])=O.[Na+].Cl[Sn]Cl>Cl.O>[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:7]([C:9]1[CH:10]=[C:11]([C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)[CH:12]=[C:13]([NH:15][NH2:23])[CH:14]=1)=[O:8])[CH3:5]

참가 물질

6

반응물 3

HCID 24479Stannous ChlorideHCID 23668193Sodium NitriteHCID 595997035-Amino-4'-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide

생성물 1

HCID 57770617HCID 57770617, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

5-Amino-4′-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide (596 mg, 2 mmol) was dissolved in 6 mL of concentrated HCl and stirred for 15 minutes at 0° C. To the reaction mixture was added a solution of NaNO2 (138 mg, 2 mmol) in water (1.5 mL) dropwise at 0° C. The mixture was stirred for 30 minutes, and then a solution of SnCl2 (4.5 mmol, 189.6 mg) in 2 mL of concentrated HCl was added dropwise. A precipitate began to form immediately. After stirring for another 30 minutes, the resulting 5-hydrazino-4′-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide was isolated as a hydrochloride salt by filtration and immediately used in the next step.

후처리

  1. stirringThe mixture was stirred for 30 minutes
  2. customto form immediately
  3. stirringAfter stirring for another 30 minutes

출처 및 근거

ORD 기록
ord-36281800c5c14e2bbac64d5b027674e8
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440708B2

반응 노트

불러오는 중…