Diethyl Oxalate → Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate

HRID 2093104

반응식

HRID 2093104 반응식
[O-]CC.[Na+].[C:5]([O:12][CH2:13][CH3:14])(=[O:11])[C:6]([O:8]CC)=O.[CH3:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23]>C1(C)C=CC=CC=1>[N+:22]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:16]=1[CH2:15][C:6](=[O:8])[C:5]([O:12][CH2:13][CH3:14])=[O:11])([O-:24])=[O:23]

참가 물질

5

반응물 3

HCID 7268Diethyl OxalateHCID 5218284-Methyl-3-nitropyridineHCID 2723922Sodium ethoxide

생성물 1

HCID 23269548Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of freshly prepared sodium ethoxide was added diethyl oxalate (1.5 eq.) followed by 4-methyl-3-nitro pyridine (1 eq.) in toluene and reaction mixture was stirred overnight. It was then concentrated under reduced pressure and acidified with acetic acid to obtained red solid, which on further purification, by column chromatography provided the ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate.

후처리

  1. concentrationIt was then concentrated under reduced pressure
  2. customto obtained red solid, which
  3. customon further purification

출처 및 근거

ORD 기록
ord-833d403d014e41518e19f7df95ba7f70
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440830B2

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