Potassium Hydroxide → 6-Aminoquinazoline

HRID 2095157노트

반응식

HRID 2095157 반응식
Cl[Sn]Cl.[N+:4]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][N:11]=[CH:10]2)([O-])=O.[OH-].[K+]>Cl>[NH2:4][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][N:11]=[CH:10]2

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 6002116-Nitroquinazoline

생성물 1

HCID 5892886-Aminoquinazoline

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매2회

실험 절차

SnCl2 (8.5 g) dissolved in 8.5 mL of conc. HCl was added to the solution of 6-nitroquinazoline in 42.5 mL of 6 N HCl at 0° C. The reaction mixture was neutralized with KOH 10 minutes later and then extracted with diethyl ether (Et2O) and EtOAc. The product 6-aminoquinazoline was obtained (0.67 g) after the removal of the solvent.

후처리

  1. extractionextracted with diethyl ether (Et2O) and EtOAc

출처 및 근거

ORD 기록
ord-c28f91cc0c7247d8b3fb3eb3b67f240b
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445694B2

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