반응식
[H-].[Na+].Cl[C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:15][CH3:16])=[C:11]([F:14])[CH:12]=2)[CH:7]=[C:6]([NH:17][C:18]2[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=2)[N:5]=1.[C:24]([OH:27])(=O)[CH3:25].[CH3:28]OCCOC>>[F:14][C:11]1[CH:12]=[C:13]2[C:8]([CH:7]=[C:6]([NH:17][C:18]3[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=3)[N:5]=[C:4]2[O:27][CH:24]([CH3:25])[CH3:28])=[CH:9][C:10]=1[O:15][CH3:16]참가 물질
5
반응 조건
- 온도
- 180 °C
실험 절차
NaH (155 mg) was added to a solution of ispropanol (500 mg) in DME (2 ml) and stirred for 1 hour. 1-Chloro-7-fluoro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (100 mg) (example 9B) was added to the mixture, and the mixture was heated at 180° C. for 30 minutes under microwave irradiation. The reaction mixture was acidified to PH=7 with acetic acid and purified by preparative LC-MS to give (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 331 (MH+).
후처리
- custompurified by preparative LC-MS
출처 및 근거
- ORD 기록
- ord-0ac85877e82249508c88f51e0b824eab
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07572809B2
연결된 노트
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