반응식
[H-].[Na+].[N:3]1([CH2:9][CH2:10][OH:11])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.F[C:13]1[CH:22]=[C:21]2[C:16]([CH:17]=[C:18]([NH:27][C:28]3[CH:32]=[C:31]([CH3:33])[NH:30][N:29]=3)[N:19]=[C:20]2[O:23][CH:24]([CH3:26])[CH3:25])=[CH:15][C:14]=1[O:34][CH3:35]>C(O)(=O)C>[CH:24]([O:23][C:20]1[C:21]2[C:16](=[CH:15][C:14]([O:34][CH3:35])=[C:13]([O:11][CH2:10][CH2:9][N:3]3[CH2:8][CH2:7][O:6][CH2:5][CH2:4]3)[CH:22]=2)[CH:17]=[C:18]([NH:27][C:28]2[CH:32]=[C:31]([CH3:33])[NH:30][N:29]=2)[N:19]=1)([CH3:26])[CH3:25]참가 물질
5
반응물 3
생성물 1
시약·촉매·용매 1
반응 조건
- 온도
- 180 °C
실험 절차
NaH (155 mg) was added to a solution of 2-Morpholin-4-yl-ethanol (2 ml) and stirred for 1 hour. (7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (100 mg) was added to the mixture, and the mixture was heated at 180° C. for 1 hour under microwave irradiation. The reaction mixture was acidified to PH=7 with acetic acid and purified by preparative LC-MS to give [1-Isopropoxy-6-methoxy-7-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine (28 mg). LC-MS: m/e 442(MH+).
후처리
- custompurified by preparative LC-MS
출처 및 근거
- ORD 기록
- ord-244937dffefa474c9910e9f54b65e208
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07572809B2
연결된 노트
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