Hydrochloric Acid → 3-Benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylic acid

HRID 2102260노트

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HRID 2102260 반응식
[CH2:1]([O:8][C:9]1[C:13]([C:14]([O:16]CC)=[O:15])=[C:12]([Br:19])[N:11]([CH:20]([CH3:22])[CH3:21])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O1CCOCC1>[CH2:1]([O:8][C:9]1[C:13]([C:14]([OH:16])=[O:15])=[C:12]([Br:19])[N:11]([CH:20]([CH3:22])[CH3:21])[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23113375HCID 23113375, 화합물

생성물 1

HCID 230795363-Benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylic acid수율 64.7%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
100 °C

실험 절차

Ethyl 3-benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylate (7.7 g) was suspended in 1,4-dioxane (19 mL) and 20% sodium hydroxide aqueous solution (19 mL) was added to the suspension. The mixture was stirred at 100° C. for 8 hours. After the reaction mixture was cooled, the reaction mixture was poured into 2 mol/L hydrochloric acid (100 mL) and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 4.6 g of the title compound.

후처리

  1. temperatureAfter the reaction mixture was cooled
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-cb4abe983e9e4c80abe4022d4321b293
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576064B2

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