Hydrochloric Acid → 3-Benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylic acid

HRID 2102332노트

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HRID 2102332 반응식
C([O:3][C:4]([C:6]1[C:7]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:8][N:9]([CH:12]([CH3:14])[CH3:13])[C:10]=1[Br:11])=[O:5])C.[OH-].[Na+].Cl>O1CCOCC1>[CH2:16]([O:15][C:7]1[C:6]([C:4]([OH:5])=[O:3])=[C:10]([Br:11])[N:9]([CH:12]([CH3:14])[CH3:13])[N:8]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23113375HCID 23113375, 화합물

생성물 1

HCID 230795363-Benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylic acid수율 64.7%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
100 °C

실험 절차

3-Benzyloxy-5-bromo-1-isopropylpyrazole-4-carboxylic acid ethyl ester (7.7 g) was suspended into 1,4-dioxan (19 mL), and 20% sodium hydroxide aqueous solution (19 mL) was added to the suspension. The mixture was stirred at 100° C. for 8 hours. After the mixture was cooled, the reaction mixture was poured into 2 mol/L hydrochloric acid (100 mL). The mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (4.6 g).

후처리

  1. additionwas added to the suspension
  2. temperatureAfter the mixture was cooled
  3. extractionThe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-e97216e061d84bcd8f5f3375cee8cc79
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576063B2

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