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Hydrochloric Acid → N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-6-(4-{1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenyl)hex-5-enamide

HRID 2104930
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HRID 2104930 반응식
[CH3:1][N:2]([CH2:46][CH:47]([OH:56])[CH:48]([OH:55])[CH:49]([OH:54])[CH:50]([OH:53])[CH2:51][OH:52])[C:3](=[O:45])[CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH:18]([CH2:19][CH2:20][CH:21]([O:29][Si](C(C)(C)C)(C)C)[C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[C:17](=[O:37])[N:16]2[C:38]2[CH:43]=[CH:42][C:41]([F:44])=[CH:40][CH:39]=2)=[CH:11][CH:10]=1.Cl.[OH-].[Na+]>CO>[CH3:1][N:2]([CH2:46][CH:47]([OH:56])[CH:48]([OH:55])[CH:49]([OH:54])[CH:50]([OH:53])[CH2:51][OH:52])[C:3](=[O:45])[CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[CH:18]([CH2:19][CH2:20][CH:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[OH:29])[C:17](=[O:37])[N:16]2[C:38]2[CH:39]=[CH:40][C:41]([F:44])=[CH:42][CH:43]=2)=[CH:13][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68552127N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-6-{4-[3-[3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenyl}hex-5-enamide

생성물 1

HCID 68551149N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-6-(4-{1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenyl)hex-5-enamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

70 mg of N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-6-{4-[3-[3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenyl}hex-5-enamide are dissolved in 6 ml of methanol. 0.1 N HCl(aq) is then added, and the mixture is stirred at room temperature overnight. The mixture is then neutralized with 1 N aqueous sodium hydroxide solution and concentrated using a rotary evaporator. The residue is stirred with dichloromethane and filtered and the mother liquor is concentrated using a rotary evaporator. The product is obtained following purification by preparative HPLC: C31H44F2N2O8 (682) MS (ESI): M+-18

후처리

  1. concentrationconcentrated
  2. customa rotary evaporator
  3. stirringThe residue is stirred with dichloromethane
  4. filtrationfiltered
  5. concentrationthe mother liquor is concentrated
  6. customa rotary evaporator
  7. customThe product is obtained
  8. custompurification by preparative HPLC

출처 및 근거

ORD 기록
ord-d621314d504249e3b925ea9cb978f12d
출처 데이터셋
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07576200B2

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