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Methanol → 3-(1-ethoxycarbonylpentoxy)-1-phenyl-1,2,4-1H-triazole

HRID 2106577
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반응식

HRID 2106577 반응식
[Na].CO.[OH:4][C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:6]=1.Br[CH:17]([CH2:23][CH2:24][CH2:25][CH3:26])[C:18]([O:20][CH2:21][CH3:22])=[O:19]>CS(C)=O>[CH2:21]([O:20][C:18]([CH:17]([O:4][C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:6]=1)[CH2:23][CH2:24][CH2:25][CH3:26])=[O:19])[CH3:22]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 887MethanolHCID 79072Ethyl 2-bromohexanoateHCID 5360545SodiumHCID 178517978HCID 178517978, 화합물

생성물 1

HCID 150162523-(1-ethoxycarbonylpentoxy)-1-phenyl-1,2,4-1H-triazole수율 27.7%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매
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실험 절차

The process was carried out as shown in Example 7 above, beginning with 1.4 g of sodium, 30 ml of methanol, 150 ml of dimethylsulfoxide, 10 g of 3-hydroxy-1-phenyl-1,2,4-1H-triazole and 13.8 g of ethyl 2-bromohexanoate. The product was distilled at 205° and 1 mm of mercury to obtain 5.2 g of the desired product, an oil.

후처리

  1. distillationThe product was distilled at 205°

출처 및 근거

ORD 기록
ord-ead8a7bf3c5447a3a02cd77f33518811
출처 데이터셋
uspto-grants-1990_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04931083

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