Sodium hydride → Ethyl 2-{[1-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]oxy}propanoate

HRID 2106579노트

반응식

HRID 2106579 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10]([OH:13])=[N:9]2)=[CH:4][CH:3]=1.[H-].[Na+].Br[CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]>CS(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:23])=[N:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 79040Ethyl 2-bromopropionateHCID 178518003HCID 178518003, 화합물

생성물 1

HCID 163820Ethyl 2-{[1-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]oxy}propanoate

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Six g of 1-(4-chlorophenyl)-3-hydroxy-1,2,4-1H-triazole was added to a suspension of 1.5 g of sodium hydride in 225 ml of dimethylsulfoxide. The mixture was heated on the steam bath for 90 minutes. Then 5.5 g of ethyl 2-bromopropionate was added and the mixture was heated for 90 minutes more. It was then cooled and poured over ice-water, and the solid was collected, dried and recrystallized from toluene to obtain 1.5 g of the desired product, m.p. 62°-64°.

후처리

  1. temperatureThe mixture was heated on the steam bath for 90 minutes
  2. temperaturethe mixture was heated for 90 minutes more
  3. temperatureIt was then cooled
  4. customthe solid was collected
  5. customdried
  6. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-3c81752852e9487eb4db2b13c5311517
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04931083

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