Hydrochloric Acid → 4-Acetamidosalicylic acid

HRID 2107017

반응식

HRID 2107017 반응식
[OH:1][C:2]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:3]=1[C:4]([O-:6])=[O:5].[Na+].Cl.[C:14](OC(=O)C)(=[O:16])[CH3:15]>O>[OH:1][C:2]1[CH:10]=[C:9]([NH:11][C:14](=[O:16])[CH3:15])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 2724368Aminosalicylate sodium anhydrous

생성물 1

HCID 655094-Acetamidosalicylic acid수율 56%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
100 °C

실험 절차

Sodium 2-hydroxy-4-aminobenzoate (76 g, 0.437 mole) was dissolved in water (2-300 ml) and concentrated hydrochloric acid (36.2 ml) was added after which the precipitated crystalline free acid was isolated by filtration. The acid was suspended in water (700 ml), acetic anhydride (48 ml) was added and the mixture was heated to about 100° C. (supplied with a reflux condenser) for 15 minutes under nitrogen. After cooling, the crystalline material was filtered off and dried in vacuo to give the title compound (48 g, 56%), m.p. 221°-223° C. Found (Calc. for C9H9NO4) C 55.14 (55.38), H 4.73 (4.62), N 7.12 (7.18).

후처리

  1. customwas isolated by filtration
  2. temperatureAfter cooling
  3. filtrationthe crystalline material was filtered off
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-b629cd53f4a44aa783759b3f39a6ea85
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04933330

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