Hydrochloric Acid → 5-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

HRID 2107035노트

반응식

HRID 2107035 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][C:6]1([CH3:16])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15].[Cl:17][CH2:18][C:19](Cl)=[O:20].Cl>CN(C=O)C>[Cl:17][CH2:18][C:19]([C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:15])[C:6]2([CH3:16])[CH3:5])=[O:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 3131003,3-Dimethyl-1,3-dihydro-indol-2-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 107523795-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

13.3 g aluminium chloride and 2.2 ml DMF were mixed and heated with stirring, at 70° C. during 15 min. After cooling to 40° C., 1.5 g 1,3-dihydro-3,3-dimethyl-2H-indol-2-one and 1.1 g 2-chloroacetyl chloride were added and stirred at 70° C. for 45 min. The mixture was poured onto 50 g ice and 10 ml 10N HCl and extracted with 3×75 ml ethyl acetate.

후처리

  1. temperatureheated
  2. temperatureAfter cooling to 40° C.
  3. stirringstirred at 70° C. for 45 min
  4. extractionextracted with 3×75 ml ethyl acetate

출처 및 근거

ORD 기록
ord-264fb957ab7b49d5846a9d96469283e1
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04933336

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