Sodium Hydroxide → Ethyl 3-methoxy-7-chlorothieno[3,2-b]pyridine-6-carboxylate

반응식

[CH3:1][O:2][C:3]1[C:7]2[NH:8][CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:11](=O)[C:6]=2[S:5][CH:4]=1.[OH-].[Na+].P(Cl)(Cl)([Cl:22])=O>>[CH3:1][O:2][C:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:11]([Cl:22])=[C:6]2[S:5][CH:4]=1

참가 물질

반응물 3

HCID 14798Sodium Hydroxide

HCID 24813Phosphorus oxychloride

HCID 230461573-Methoxy-6-ethoxycarbonylthieno[3,2-b]pyridin-7-(4H)-one

생성물 1

HCID 23046152Ethyl 3-methoxy-7-chlorothieno[3,2-b]pyridine-6-carboxylate

실험 절차

3-Methoxy-6-ethoxycarbonylthieno[3,2-b]pyridin-7-(4H)-one (3 g, 0.0118 mol) and phosphorus oxychloride (10 ml) was heated under reflux for one hour. The reaction mixture was poured onto ice (200 g) and stirred for 30 minutes. The mixture was then basified with 40% sodium hydroxide solution and extracted with chloroform (3×100 ml). The chloroform extracts were combined, dried over magnesium sulphate, filtered and evaporated under reduced pressure to give the title compound as a buff-colour solid, 3.2 g, m.p. 135°-137°.