Hydrogen Bromide → HCID 10872911, 화합물

HRID 2107785노트

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HRID 2107785 반응식
C(O[C@H:5]1[O:18][C@H:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[C@H:12]([O:13][C:14](=[O:16])[CH3:15])[C@H:7]([O:8][C:9](=[O:11])[CH3:10])[C@H:6]1[N:24]=[N+:25]=[N-:26])(=O)C.[BrH:27]>C(Cl)Cl.[Br-].C([N+](CC)(CC)CC)C>[C:9]([O:8][C@H:7]1[C@@H:12]([O:13][C:14](=[O:16])[CH3:15])[C@@H:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:18][C@H:5]([Br:27])[C@@H:6]1[N:24]=[N+:25]=[N-:26])(=[O:11])[CH3:10]

참가 물질

5

반응물 2

HCID 260Hydrogen BromideHCID 128212011,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranose

생성물 1

HCID 10872911HCID 10872911, 화합물

시약·촉매·용매 2

HCID 6285Tetraethylammonium Bromide촉매HCID 6344Dichloromethane용매2회

실험 절차

1 ,3,4,6- Tetra-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranose (14) (500 mg) was dissolved in 50 mL CH2Cl2 (anhydrous), treated with 50 mL of CH2Cl2 saturated with HBr at 0° C., and stirred for two hours. Then 2 g of tetraethyl ammonium bromide was added and stirred overnight. Next, the solution was washed with 100 mL ice-cold water and concentrated. The residue was crystallized from ethyl ether and pentane to give 400 mg of 3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide (18).

후처리

  1. stirringstirred overnight
  2. washNext, the solution was washed with 100 mL ice-cold water
  3. concentrationconcentrated
  4. customThe residue was crystallized from ethyl ether and pentane

출처 및 근거

ORD 기록
ord-7dbba2ce2d814d939c3daf244fc584c4
출처 데이터셋
uspto-grants-1990_06
특허 번호
US04935503

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