Acrylonitrile → 1-Propanamine, 3-(octadecyloxy)-

HRID 2112362노트

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HRID 2112362 반응식
[CH2:1]([OH:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[C:20](#[N:23])[CH:21]=[CH2:22]>[Ni].[OH-].[K+].[OH-].[Na+].O>[CH2:1]([O:19][CH2:22][CH2:21][CH2:20][NH2:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

7

반응물 2

HCID 7855AcrylonitrileHCID 8221Stearyl Alcohol

생성물 1

HCID 820871-Propanamine, 3-(octadecyloxy)-수율 89.8%

시약·촉매·용매 4

HCID 935Nickel촉매HCID 14797Potassium Hydroxide촉매HCID 14798Sodium Hydroxide촉매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

An autoclave equipped with a stirrer and a temperature gage was charged with 270.5 g of octadecanol and 0.1 g of potassium hydroxide and the mixture was dehydrated at 120° C. under a vacuum of 2.6 kPa for one hour. Then, the mixture was cooled to 60° C. and 58.4 g of acrylonitrile was introduced into the autoclave over one hour, which was then kept as it was for one hour to complete the reaction. Next, 1.9 g of Raney nickel, 0.3 g of sodium hydroxide and 16.1 g of ion exchange water were introduced into the autoclave, which was then reacted for hydrogenation and reduction at 130° C. for 3 hours. Then, the reaction mixture was subjected to filtration to remove the catalyst, distilled and refined to obtain 294.3 g of a corresponding 3-octadecyloxypropylamine.

후처리

  1. customAn autoclave equipped with a stirrer
  2. waitwas for one hour
  3. customthe reaction
  4. customwas then reacted for hydrogenation and reduction at 130° C. for 3 hours
  5. filtrationThen, the reaction mixture was subjected to filtration
  6. customto remove the catalyst
  7. distillationdistilled

출처 및 근거

ORD 기록
ord-2e11ca312f314a978fa4c059cdf7188e
출처 데이터셋
uspto-grants-2009_04
특허 번호
US07524486B2

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