Dissolve 2-methoxymethyl-4-(4-trifluoromethyl-phenylamino)-7-(3-trifluoromethyl-pyridin-2-yl)-[1,8]napthyridine-3-carboxylic acid methyl ester (150 mg, 0.279 mmol) in a solution of MeOH (6 mL), H2O (2 mL), and LiOH.H2O (58.6 mg, 1.40 mmol). Stir the mixture overnight at room temperature. Add water (30 mL) and acidify the mixture with 3 N HCl. Extract with CH2Cl2 (2×40 mL). Dry the combined organic extracts over Na2SO4. Remove the solvent under reduced pressure and chromatograph the crude product on silica gel eluting with CH2Cl2/MeOH/AcOH (95:5:1) to yield the title compound. MS 523.18 (M+1).
