Ammonium Acetate → 5-Amino-cyclooctanecarbonitrile
반응식
O=[C:2]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]#[N:11])[CH2:5][CH2:4][CH2:3]1.C([O-])(=O)C.[NH4+].C([BH3-])#[N:18].[Na+]>CO>[NH2:18][CH:2]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]#[N:11])[CH2:5][CH2:4][CH2:3]1참가 물질
5
실험 절차
The product of Example 10B (0.259 g, 1.71 mmol), ammonium acetate (1.32 g, 17.14 mmol), and sodium cyanoborohydride (0.43 g, 6.84 mmol) was stirred in methanol (8 mL) for twelve hours. The solvent was evaporated and the residue was partitioned with dichloromethane and water. The organic phase was washed with NaHCO3 solution and brine, dried (Na2SO4), filtered, and evaporated. The crude title compound was used in the following step without further purification.
후처리
- customThe solvent was evaporated
- customthe residue was partitioned with dichloromethane and water
- washThe organic phase was washed with NaHCO3 solution and brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customevaporated
- customThe crude title compound was used in the following step without further purification
출처 및 근거
- ORD 기록
- ord-ca33800ebf414009a93d5b541a48443e
- 출처 데이터셋
- uspto-grants-2008_10
- 특허 번호
- US07435833B2
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