Hydrochloric Acid → 5-Fluoro-6-hydroxynaphthalene-1-carboxylic acid

HRID 2115856노트

반응식

HRID 2115856 반응식
[OH-].[Na+].[F:3][C:4]1[C:13]([OH:14])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[C:15]([O:17]C)=[O:16].Cl>O.CO>[F:3][C:4]1[C:13]([OH:14])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[C:15]([OH:17])=[O:16]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24823729Methyl 5-fluoro-6-hydroxynaphthalene-1-carboxylate

생성물 1

HCID 248246045-Fluoro-6-hydroxynaphthalene-1-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

Sodium hydroxide (116 g, 2.9 mol) was dissolved in 100 mL water and added to a solution of methyl 5-fluoro-6-hydroxy-1-naphthoate (8.56 g, 38.9 mmol) in methanol (200 mL). The mixture was refluxed at 80° C. for 2 h. The mixture was allowed to cool to RT, then poured into 6N HCl in ice. The pH was adjusted to 3 to give a fine purple/pink solid. The title compound was isolated by centrifuge (with some salts).

후처리

  1. temperatureto cool to RT
  2. customto give a fine purple/pink solid

출처 및 근거

ORD 기록
ord-a66f1816767e4f3d92365d740a708d6d
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435823B2

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