Hydrochloric Acid → 2-Acetamido-1,3-thiazole-4-carboxylic acid

HRID 2117849노트

반응식

HRID 2117849 반응식
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12]CC)=[O:11])[N:9]=1)(=[O:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:12])=[O:11])[N:9]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702548Ethyl 2-acetamido-1,3-thiazole-4-carboxylate

생성물 1

HCID 8401132-Acetamido-1,3-thiazole-4-carboxylic acid수율 74.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl 2-(acetylamino)-1,3-thiazole-4-carboxylate (2 g), 2N sodium hydroxide (7 ml) and methanol (13 ml) was stirred at ambient temperature for 5 hours. The reaction mixture was neutralized by 1N hydrochloric acid (14 ml). The precipitated crystals were filtered and washed with water to give 2-(acetylamino)-1,3-thiazole-4-carboxylic acid (1.3 g).

후처리

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-a0d23b7250f747578c103f764b01f443
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442715B2

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