[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9](O)[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:25].[OH-].[Na+]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([Cl:25])[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=123.2 g of 4-(4-bromophenyl)-2-(2,6-difluorophenyl)-3-hydroxypyrimidine and 100 ml of POCl3 are mixed and stirred for one hour at 110° C. The reaction mixture is slowly poured into a solution of 250 g of NaOH (solid) in water, and filtered. After dissolving the precipitate in ethyl acetate, drying with magnesium sulfate, filtering and concentrating, the title compound is obtained with a melting point of 146-148° C. (compound 3.354).
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