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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-Hydroxy-p-toluic acid → Benzoic acid, 2-ethoxy-4-methyl-, ethyl ester

HRID 2120001
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HRID 2120001 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:15]C(O)=O)[CH:7]=[CH:8][C:9]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:2].CC1C=C(O)C(=CC=1)C(O)=O.C(Br)C.S1(CCCC1)(=O)=O.C(=O)([O-])[O-].[K+].[K+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O.CS(C)=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH3:15])[CH:7]=[CH:8][C:9]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:2]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

9

반응물 6

HCID 57882-Hydroxy-p-toluic acidHCID 6332Ethyl BromideHCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 31347SulfolaneHCID 101312123-Ethoxy-4-ethoxycarbonylphenylacetic acid

생성물 1

HCID 11816602
Benzoic acid, 2-ethoxy-4-methyl-, ethyl ester

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 6228Dimethylformamide용매

실험 절차

More particularly, the present invention relates to a process for the preparation of 3-ethoxy-4-(ethoxycarbonyl)phenyl acetic acid of Formula I, comprising reacting 4-methylsalicylic acid of Formula III, with ethylbromide in a dipolar aprotic solvent at a selected temperature within a range of ambient to 100° C., preferably 30-40° C. during a period of one to several hours. The suitable dipolar aprotic solvent is selected from the group consisting of dimethylsulphoxide, N, N-dimethyl formamide, sulfolane and N-methyl-1-pyrrolidone. The reaction is carried out in the presence of an inorganic base, preferably selected from the group consisting of potassium carbonate and sodium carbonate. The reaction is worked up following the conventional method to afford ethyl 2-ethoxy-4-methylbenzoate of Formula IV in practically quantitative yield. The compound of Formula IV is then reacted with lithium diisopropyl amide (LDA) of Formula VIII,

출처 및 근거

ORD 기록
ord-dd358747415b4122a021458a22ea778d
출처 데이터셋
uspto-grants-2004_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06686497B1

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