Hydrochloric Acid → 3-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid

HRID 2120707노트

반응식

HRID 2120707 반응식
C([O:3][C:4](=[O:28])[CH2:5][CH:6]([C:21]1[CH:22]=[N:23][C:24]([CH3:27])=[N:25][CH:26]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1)C.[OH-].[Na+].Cl>O1CCOCC1>[CH3:27][C:24]1[N:25]=[CH:26][C:21]([CH:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[N:16]=[CH:17][CH:18]=[CH:19][N:20]=2)[CH2:5][C:4]([OH:28])=[O:3])=[CH:22][N:23]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 206224843-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid ethyl ester

생성물 1

HCID 234355223-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid수율 57.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 24-8 (170 mg, 0.441 mmol) in 1,4-dioxane (2 mL) was treated with 1M aqueous NaOH (1.50 mL) at room temperature (90 min). The reaction was neutralized with 1M aqueous HCl (1.50 mL) and the solvents were removed in vacuo. PCTLC (SiO2, 2 mm, 10% MeOH; 25% EtOAc, 65% CHCl3) afforded 24-9 (90 mg).

후처리

  1. customthe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-b69c956a6f6a43edadd8ac83724ac8be
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06693101B2

반응 노트

불러오는 중…