Tetrahydrofuran → 5-[4-Fluoro-5-iodo-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine

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[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[F:1][c:2]1[cH:3][c:4]([CH:17]([CH3:18])[CH3:19])[c:5]([O:6][c:7]2[c:8]([NH2:14])[n:9][c:10]([NH2:13])[n:11][cH:12]2)[cH:15][cH:16]1.[F:20][C:21]([S:22]([OH:23])(=[O:24])=[O:25])([F:26])[F:27].[I:28][N:29]1[C:30](=[O:31])[CH2:32][CH2:33][C:34]1=[O:35]>>[F:1][c:2]1[cH:3][c:4]([CH:17]([CH3:18])[CH3:19])[c:5]([O:6][c:7]2[c:8]([NH2:14])[n:9][c:10]([NH2:13])[n:11][cH:12]2)[cH:15][c:16]1[I:28]