Cyanoacetamide → alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide

HRID 2163573

반응식

HRID 2163573 반응식
N1CCCCC1.[C:7]([CH2:9][C:10]([NH2:12])=[O:11])#[N:8].[N+:13]([C:16]1[C:21]([CH:22]=O)=[CH:20][C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=1)([O-:15])=[O:14]>CO>[C:7]([C:9](=[CH:22][C:21]1[CH:20]=[C:19]([O:24][CH3:25])[C:18]([O:26][CH3:27])=[CH:17][C:16]=1[N+:13]([O-:15])=[O:14])[C:10]([NH2:12])=[O:11])#[N:8]

참가 물질

5

반응물 3

HCID 7898CyanoacetamideHCID 8082PiperidineHCID 885056-Nitroveratraldehyde

생성물 1

HCID 4145653alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Piperidine (2.1 g., 0.0237mole) and 2-cyanoacetamide (22.0g., 0.263 mole) are added to a slurry of 6-nitroveratraldehyde (50.0 g., 0.237 mole) in methanol (500 ml.). The mixture is heated to reflux for two hours, and then cooled in an ice bath and filtered. The bright yellow filter cake is washed with cold isopropanol (300 ml.) and then air dried. Yield = 60.1 g. (93%); m.p. 265°-266° C.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux for two hours
  3. temperaturecooled in an ice bath
  4. filtrationfiltered
  5. washThe bright yellow filter cake is washed with cold isopropanol (300 ml.)
  6. customair dried

출처 및 근거

ORD 기록
ord-2e88bbac5f924a2cb8269c8b139714cc
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04134981

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