Sodium Chloride → Aldosterone

HRID 2163662노트

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HRID 2163662 반응식
[Cl-].[Na+].CC([O:6][CH2:7][C:8]([C@@H:10]1[C@@:14]2([CH:30]=[O:31])[CH2:15][C@H:16]([OH:29])[C@@H:17]3[C@:27]4([CH3:28])[C:21](=[CH:22][C:23]([CH2:25][CH2:26]4)=[O:24])[CH2:20][CH2:19][C@H:18]3[C@@H:13]2[CH2:12][CH2:11]1)=[O:9])=O.[Na].[K]>O.O.O>[CH3:28][C@@:27]12[C@H:17]3[C@@H:16]([OH:29])[CH2:15][C@:14]4([CH:30]=[O:31])[C@@H:10]([C:8]([CH2:7][OH:6])=[O:9])[CH2:11][CH2:12][C@H:13]4[C@@H:18]3[CH2:19][CH2:20][C:21]1=[CH:22][C:23](=[O:24])[CH2:25][CH2:26]2

참가 물질

7

반응물 4

HCID 5234Sodium ChlorideHCID 101637Aldosterone acetateHCID 5360545SodiumHCID 5462222Potassium

생성물 1

HCID 5839Aldosterone

시약·촉매·용매 2

HCID 962Water용매HCID 447138Water dimer용매

실험 절차

Male rats of the Sprague-Dawley strain weighing about 180 g were surrenalectomized and at that moment, the rats received with their drinking water physiological serum. On the 4th day, the animals were fasted for 16 hours and then received as drinking water water containing 5% glucose. The test product was administered orally at the end of 16 hours in the form of a suspension in 0.25% carboxymethylcellulose. One hour after the administration of the product, they received intraperitoneally a surcharge of aqueous sodium chloride at a rate of 5 ml per 100 g of body weight of 9% physiological serum and subcutaneously 1 μg/kg of an alcoholic solution of 2.5% of aldosterone acetate. The animals were placed in diuresis cages without food or drink for 4 hours. At the end of this time, a miction was forced by pressure on the bladder and the volume of urine was adjusted to 50 ml and the amount of sodium and potassium was determined with an autoanalyser. The results expressed as the percentage of inhibition of the activity of 1 μg/kg of aldosterone monoacetate injected subcutaneously with the ratio of ##EQU1## in the surrenalectomized rats is reported in the following Table.

후처리

  1. customOne hour
  2. waitThe animals were placed in diuresis cages without food or drink for 4 hours

출처 및 근거

ORD 기록
ord-b824acbd780c4475be907b1fce0f82ff
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04136179

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