Potassium Carbonate → N-(4-[3-Phenylpropyl]piperidinocarbonyl)-2-phenylethenesulfonamide

HRID 2163690노트

반응식

HRID 2163690 반응식
[C:1]1([CH:7]=[CH:8][S:9]([NH2:12])(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]2[CH2:33][CH2:32][N:31]([C:34](Cl)=[O:35])[CH2:30][CH2:29]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[Na]>C(Cl)(Cl)Cl>[C:19]1([CH2:25][CH2:26][CH2:27][CH:28]2[CH2:29][CH2:30][N:31]([C:34]([NH:12][S:9]([CH:8]=[CH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:10])=[O:11])=[O:35])[CH2:32][CH2:33]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 2575012-PhenylethenesulfonamideHCID 5360545SodiumHCID 227508054-(3-Phenylpropyl)piperidine-1-carbonyl chloride

생성물 1

HCID 54287481N-(4-[3-Phenylpropyl]piperidinocarbonyl)-2-phenylethenesulfonamide수율 41%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A stirred mixture of 1.83 g. (0.01 mole) of 2-phenylethenesulfonamide, 3.45 g. (0.025 mole) of potassium carbonate and 4.0 g. (0.015 mole) of 4-(3-phenylpropyl)piperidinocarbonyl chloride, in 75 ml. of chloroform is heated under reflux for 22 hours. The solvent is then removed by evaporation in vacuo, and to the residue is added 75 ml. of 0.5N sodium hydroxide and 35 ml. of ether. The mixture is stirred for 1 hour, and then the solid which remains undissolved is removed by filtration. This affords 1.84 g. (ca. 41% yield) of the title compound as a mixture of its sodium and potassium salts.

후처리

  1. additionA stirred mixture of 1.83 g
  2. temperatureunder reflux for 22 hours
  3. customThe solvent is then removed by evaporation in vacuo
  4. additionto the residue is added 75 ml
  5. customthe solid which remains undissolved is removed by filtration

출처 및 근거

ORD 기록
ord-83ccda5ff10f42358c6e6ddce6feb5fa
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04136180

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